Medicine Information

Alzheimers Toxin May Be Key To Slowing Disease


Australian scientists say they have identified a toxin which plays a key role in the onset of Alzheimer's, raising hope that a drug targeting the toxin could be developed to slow the degenerative brain disease.

The toxin, called quinolinic acid, kills nerve cells in the brain, leading to dysfunction and death, the scientists said.

"Quinolinic acid may not be the cause of Alzheimer's disease, but it plays a key role in its progression," Alzheimer's researcher Dr Karen Cullen from the University of Sydney said in a statement. "It's the smoking gun, if you like."

"While we won't be able to prevent people from getting Alzheimer's disease, we may eventually, with the use of drugs, be able to slow down the progression."

Alzheimer's is a brain-destroying disease that affects millions of people around the world. As the population gets steadily older, experts estimate numbers will balloon to as many as 16 million in the United States alone by 2015.

More than 200,000 people have Alzheimer's disease in Australia and the number is expected to rise to 730,000 by 2050.

Outward symptoms start with memory loss, which progresses to complete helplessness as brain cells are destroyed. In the brain, neurons die as messy plaques and tangles of protein form.

The Alzheimer's research team from Sydney's St Vincent's Hospital, the University of Sydney and Japan's Hokkaido University found quinolinic acid neurotoxicity in the brains of dementia patients.

Quinolinic acid is part of a biochemical pathway called the kynurenine pathway which is also found in other brain disorders, including Huntington's disease and schizophrenia.

The scientists said there were several drugs in an advanced stage of development for other conditions which targeted this pathway and that these drugs, which still need to be tested, could be used to complement other treatments for Alzheimer's.

"Building on what we've found and others have found, it's likely that they would have significant effect," said Professor Bruce Brew, director of neurology at St Vincent's Hospital.

Mike Freije
http://www.health-shop.info
http://www.health-shop.biz


MORE RESOURCES:
This RSS feed URL is deprecated, please update. New URLs can be found in the footers at https://news.google.com/news


KTVZ

Four Jefferson Co. youth OD on cold medicine, hospitalized
KTVZ
The Jefferson County District Attorney's Office and Juvenile Department and Madras Police warned parents Tuesday about a spike in juvenile abuse of over-the-counter cold medicines containing dextromethorphan -- which put four youth in the hospital with ...



Forbes

Medicine and Dentistry: Undoing an Illogical 150-Year Divide
Forbes
It's no secret that medicine and dentistry have evolved an unnatural professional separation that is helpful to no one and often causes unnecessary suffering on the part of patients. But we're in a moment—driven by our greater understanding of the ...



FRANCE 24

Roots and shoots: China seeks new markets for ancient medicines
FRANCE 24
A crowd gathers at a Shanghai hospital, queuing for remedies made with plant mixtures and animal parts including scorpions and freeze-dried millipedes -- medicines that China hopes will find an audience overseas. With a history going back 2,400 years, ...

and more »


Mylan recalls batches of blood pressure medicine in US
Reuters
(Reuters) - Mylan NV said on Tuesday it would recall certain batches of blood pressure medicine valsartan in the United States after they were found to contain a probable cancer-causing impurity, the latest recall amid heightened safety concerns globally.

and more »


Healthcare IT News

Center for Connected Medicine polls top health systems about 2019 priorities
Healthcare IT News
The Center for Connected Medicine polled IT executives across 38 health systems for its 2019 Top of Mind survey. Cybersecurity continues to be the biggest concern across the industry, with telehealth and interoperability not far behind. Those topics ...

and more »


PharmaTimes

Mirati joins CR UK's Stratified Medicine Programme
PharmaTimes
Mirati Therapeutics has joined Cancer Research UK's Stratified Medicine Programme, bringing new investigational treatment options to eligible patients with advanced lung cancer. The partnership will make Mirati's experimental drug, sitravatinib ...



OncLive

Dr. Borgen on Precision Medicine in Breast Cancer
OncLive
The TAILORx trial, which was discussed at the 2018 ASCO Annual Meeting, is a perfect example of precision medicine making its way into this space, according to Borgen. Data from this trial suggested that by applying the precision medicine concept in ...



AAFP News (blog)

Bustling Clerkship Shows Family Medicine Is Never Boring
AAFP News (blog)
Not only was family medicine the first specialty I was ever interested in, it was my first third-year clerkship in medical school, too. Although I started medical school thinking family medicine was the specialty for me, it wasn't until my clinical ...



Elko Daily Free Press

Huynh joins UNR Med Elko Family Medicine Residency Program
Elko Daily Free Press
The Elko Family Medicine Residency Program aims to increase the primary care physician workforce in Elko and the surrounding areas, through the training of resident physicians under the supervision of experienced UNR Med faculty physicians.



News3LV

Pulmonary Medicine
News3LV
Pulmonary Medicine. OptumCare Lung and Allergy Care. Chronic obstructive pulmonary disease, or “COPD” is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus production ...

and more »

Google News

home | site map | Dr. Thad Thomas
© 2006