New Antidepressant Developments and Approvals
New antidepressant development, until fairly recently, was at best a random, and at worst a problematic and frustrating, process. Often, medications that were developed for one thing were discovered quite accidentally to have much more important therapeutic effects for a completely different disorder. It has been well described that some of the original antipsychotics were originally developed to assist in anesthesia, and some of the original new antidepressants were originally intended to be medications for tuberculosis or psychosis. New antidepressant development was done on a "chemical" basis; that is, guesses were made as to compounds that would be safe and effective based on chemical structures of established medications. This was very much a trial-and-error process, since very little was known about how these drugs worked and very little could be measured beyond actually giving them to a patient.
New antidepressant development always has been and always will be a partnership between efficacy (ie, whether the drug is effective) and safety (ie, whether the drug can be tolerated by a patient). There were very few ways of knowing the answers to those two questions about any given compound unless you tried it, a process not without its obvious risks. It should be noted that vagus nerve stimulation for depression clearly meets the two main FDA requirements of safety and efficacy.
Medications to treat depression; mild, severe, bipolar, or treatment-resistant, make the news most frequently, and deservedly so. Their progress and approval can potentially benefit almost 8 million Americans who suffer from some form of depression. Because there seems to be more frequency now of depression that is treatment-resistant, meaning most methods of treatment (medications, psychotherapy, electroconvulsive therapy, or a combination of more than one treatment) have failed for a patient, the approval of new antidepressants from companies like Merck, Lilly, and Pfizer, are more important than ever. This is because a new class of medication for treating depression has not been developed in over a decade.
On July 18th, 2005 the FDA approved the first ever treatment long term treatment option for depression; vagus nerve stimulation. You can learn more about this remarkable treatment at http://www.VagusNerveStimulator.com There is a free electronic newsletter to keep you up-to-date.
Charles Donovan was a patient in the FDA investigational trial of vagus nerve stimulation as a treatment for chronic or recurrent treatment-resistant depression. He was implanted with the vagus nerve stimulator in April of 2001. He chronicles his journey from the grips of depression thanks to vagus nerve stimulation therapy in his book:
Out of the Black Hole: The Patient's Guide to Vagus Nerve Stimulation and Depression
The book was exhibited at the American Psychiatric Association's Annual Meeting in May. It is available on his web site and 24 hours a day/7 days a week through the toll free number 1-888-VAGUS-88. If you use discount code FDAYES(all caps), it will save you 25% off the cost of the book and you will get automatic free shipping via U.S. Postal Priority Mail.
The book is also available through Amazon.com and Barnes & Noble.com. The discount does not apply at these two sites.
He is the founder of the http://www.VagusNerveStimulator.com Web Site
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Clinicians at the University of Pennsylvania have treated two cancer patients with CRISPR, a gene-editing technology that enables precise modifications to DNA.
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A grant will fund Baylor research to study mucosal infection (bacteria, viruses and parasites) through the use of genomics and organoid model systems ...
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Gov. Ron DeSantis recommits to Canada drug plan, insists imported medicines will be safe - Sun Sentinel
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Reducing the DUI legal limit: A spirited debate Baylor College of Medicine News
This post examines current legislation and conversation about why states should reduce the DUI / blood alcohol concentration limit from .08 to .05.
Ethical challenges of Personalized Medicine considered at Vatican workshop Vatican News
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With the hum of the election campaign and the debate of "big business," versus human interest, I decided to do a bit of muckraking into the art and science of the recent removal of Merck's Vioxx. My motivation of course; to look for clues as to the role drug companies play in our health and wellness (or lack thereof).
Testosterone Therapy in XXI Century
Nowadays many people are familiar with the appellation of "low testosterone level". What does it mean? It mean that male body produce less amounts of this hormone than necessary.
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Today there are about 70 million Americans with arthritis?that's one person out of every four who suffer both pain and the expense of this crippling disease. In one year alone, arthritis will be responsible for over half a billion dollars in lost wages.
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Why Modern Medicine is the Greatest Threat to Health
There is the underlying assumption that modernity translates into better health. A corollary of this logic is that we can live our lives pretty much as we want because we can always buy a repair.
At Last! Good News For Gout Sufferers!
Gout, an arthritis affliction with its roots in antiquity, has not always been easy to treat. The traditional medicines employed for gout have been non-steroidal anti-inflammatory drugs (NSAIDS), colchicines, probenicid (Benemid), and allopurinol (Zyloprim).
Cetyl Myristoleate for Arthrtis: Science or Speculation
There are a lot of fabulous stories about Cetyl Myristoleate (also known as CMO or CM) floating across the Internet. Mine is one of them.
Technology Over Drugs for Stress Related Tension Disorders
As much as 95% of the population suffers from some form of reoccurring stress and tension related headaches.Although not normally debilitating these headaches affect work productivity and add to the billion dollar cost of sick days and time off.
First Step To Addiction Recovery
The first step to over comming any addiction is to detoxify the body of the addictive substance. Whether it's herion, crack, or meth detoxifcation of the liver is essential to addiction recovery.
Pain in the Butt. How to Deal with Hemorrhoids?
This is very sensitive area of your body. Too private.
Mexico: Drugs Galore!
You are going to find this incredible and I assure you I am not making any of this up: You can waltz into any pharmacy (Farmacia) in Mexico and buy almost anything without a prescription. Except for controlled substances, you can get most anything you want or need simply by asking.
Fifteen Ways to Fight Heel Pain
There are many different causes of heel pain, but the most common cause is plantar fasciitis (plan * tar fash* ee * I * tis). If you experience a sharp pain in your heel when you first step down in the morning, it is most likely due to plantar fasciitis.
4 Reasons Why You Should Use Canadian Pharmacies
Let's face it: purchasing prescription drugs in the U.S.
New Company Helps Another Medical Condition Become: "Acceptable" Dinner Conversation
Recently once taboo subjects like plastic surgery have become acceptable dinner conversation. Medical conditions are no longer whispered to friends, but have instead become part of the dinner table conversation with full blown discussions on Botox, erectile dysfunction and the feared colonoscopy.
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