New Antidepressant Developments and Approvals
New antidepressant development, until fairly recently, was at best a random, and at worst a problematic and frustrating, process. Often, medications that were developed for one thing were discovered quite accidentally to have much more important therapeutic effects for a completely different disorder. It has been well described that some of the original antipsychotics were originally developed to assist in anesthesia, and some of the original new antidepressants were originally intended to be medications for tuberculosis or psychosis. New antidepressant development was done on a "chemical" basis; that is, guesses were made as to compounds that would be safe and effective based on chemical structures of established medications. This was very much a trial-and-error process, since very little was known about how these drugs worked and very little could be measured beyond actually giving them to a patient.
New antidepressant development always has been and always will be a partnership between efficacy (ie, whether the drug is effective) and safety (ie, whether the drug can be tolerated by a patient). There were very few ways of knowing the answers to those two questions about any given compound unless you tried it, a process not without its obvious risks. It should be noted that vagus nerve stimulation for depression clearly meets the two main FDA requirements of safety and efficacy.
Medications to treat depression; mild, severe, bipolar, or treatment-resistant, make the news most frequently, and deservedly so. Their progress and approval can potentially benefit almost 8 million Americans who suffer from some form of depression. Because there seems to be more frequency now of depression that is treatment-resistant, meaning most methods of treatment (medications, psychotherapy, electroconvulsive therapy, or a combination of more than one treatment) have failed for a patient, the approval of new antidepressants from companies like Merck, Lilly, and Pfizer, are more important than ever. This is because a new class of medication for treating depression has not been developed in over a decade.
On July 18th, 2005 the FDA approved the first ever treatment long term treatment option for depression; vagus nerve stimulation. You can learn more about this remarkable treatment at http://www.VagusNerveStimulator.com There is a free electronic newsletter to keep you up-to-date.
Charles Donovan was a patient in the FDA investigational trial of vagus nerve stimulation as a treatment for chronic or recurrent treatment-resistant depression. He was implanted with the vagus nerve stimulator in April of 2001. He chronicles his journey from the grips of depression thanks to vagus nerve stimulation therapy in his book:
Out of the Black Hole: The Patient's Guide to Vagus Nerve Stimulation and Depression
The book was exhibited at the American Psychiatric Association's Annual Meeting in May. It is available on his web site and 24 hours a day/7 days a week through the toll free number 1-888-VAGUS-88. If you use discount code FDAYES(all caps), it will save you 25% off the cost of the book and you will get automatic free shipping via U.S. Postal Priority Mail.
The book is also available through Amazon.com and Barnes & Noble.com. The discount does not apply at these two sites.
He is the founder of the http://www.VagusNerveStimulator.com Web Site
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Commentary: The Tribune was wrong. Medicine often involves a risk to the patient. - Salt Lake Tribune
Rethink Healthcare: Government hospitals must provide quality, affordable medicine - Economic Times (blog)
Landmark CAR-T cancer study published in the New England Journal of Medicine - EurekAlert (press release)
An Introduction to Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a very common condition, but in some ways it is still a mystery. There are many different theories about what causes the syndrome, and different doctors will give you different reasons for your illness - anything from stress to bad bacteria to food intolerance.
Bee Propolis: Synergisitc Health Care for the 21st Centruy
For well over a century modern science has progressed at a startling rate. With this increase in knowledge has come medicinal and healthcare benefits that have seen ages peak and diseases eradicated.
Top Five FAQs About Nail Fungus
What is nail fungus?Nail fungus, also known as Onychomycosis, is an organism which digests the keratin found in your fingernails and toenails. The fingernail and toenail are naturally built to be strong barriers, and resistant to fungi and other infections.
How To Save Money On Prescription Medications
If you are a regular user of prescription medications, you know that these drugs can be costly to purchase. Cutting back on drugs can be dangerous to your health, but if you are on a fixed income your choices can seem limited.
Prescription Drugs from International Pharmacies Save Elderly Money
As pointed out by *Jack Shapiro, an internationally-known healthcare marketing consultant "For the first nine months of this year, the U.S.
Why Drug Companies are Naughty and 5 Remedies to Cure the Symptoms
With the hum of the election campaign and the debate of "big business," versus human interest, I decided to do a bit of muckraking into the art and science of the recent removal of Merck's Vioxx. My motivation of course; to look for clues as to the role drug companies play in our health and wellness (or lack thereof).
Testosterone Therapy in XXI Century
Nowadays many people are familiar with the appellation of "low testosterone level". What does it mean? It mean that male body produce less amounts of this hormone than necessary.
Who Else Wants General Information on Arthritis?
Today there are about 70 million Americans with arthritis?that's one person out of every four who suffer both pain and the expense of this crippling disease. In one year alone, arthritis will be responsible for over half a billion dollars in lost wages.
Back Pain & Muscle Pain - Effective & Natural Pain Treatment Alternatives
Pain and Stress. They seem almost to go hand in hand - not only in their negative connotation, but also in their biological causes and triggers.
Increasing Patient Care and Reducing Liability in Seven Simple Steps
When an unconscious patient arrives in the ED, every hospital agrees that timely next of kin notification is vital. Not only is it important to have a family member present to comfort the patient, but to make informed decisions for his care and provide the medical history that can make the difference between life and death.
Why Modern Medicine is the Greatest Threat to Health
There is the underlying assumption that modernity translates into better health. A corollary of this logic is that we can live our lives pretty much as we want because we can always buy a repair.
At Last! Good News For Gout Sufferers!
Gout, an arthritis affliction with its roots in antiquity, has not always been easy to treat. The traditional medicines employed for gout have been non-steroidal anti-inflammatory drugs (NSAIDS), colchicines, probenicid (Benemid), and allopurinol (Zyloprim).
Cetyl Myristoleate for Arthrtis: Science or Speculation
There are a lot of fabulous stories about Cetyl Myristoleate (also known as CMO or CM) floating across the Internet. Mine is one of them.
Technology Over Drugs for Stress Related Tension Disorders
As much as 95% of the population suffers from some form of reoccurring stress and tension related headaches.Although not normally debilitating these headaches affect work productivity and add to the billion dollar cost of sick days and time off.
First Step To Addiction Recovery
The first step to over comming any addiction is to detoxify the body of the addictive substance. Whether it's herion, crack, or meth detoxifcation of the liver is essential to addiction recovery.
Pain in the Butt. How to Deal with Hemorrhoids?
This is very sensitive area of your body. Too private.
Mexico: Drugs Galore!
You are going to find this incredible and I assure you I am not making any of this up: You can waltz into any pharmacy (Farmacia) in Mexico and buy almost anything without a prescription. Except for controlled substances, you can get most anything you want or need simply by asking.
Fifteen Ways to Fight Heel Pain
There are many different causes of heel pain, but the most common cause is plantar fasciitis (plan * tar fash* ee * I * tis). If you experience a sharp pain in your heel when you first step down in the morning, it is most likely due to plantar fasciitis.
4 Reasons Why You Should Use Canadian Pharmacies
Let's face it: purchasing prescription drugs in the U.S.
New Company Helps Another Medical Condition Become: "Acceptable" Dinner Conversation
Recently once taboo subjects like plastic surgery have become acceptable dinner conversation. Medical conditions are no longer whispered to friends, but have instead become part of the dinner table conversation with full blown discussions on Botox, erectile dysfunction and the feared colonoscopy.
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